Polyene antibiotics. VIII. The structure of rimocidin.
نویسندگان
چکیده
منابع مشابه
The polyene macrolide antibiotics.
The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.
متن کاملPolyene Antifungal Antibiotics
ZYGMUNT, WALTER A. (Mead Johnson Research Center, Evansville, Ind.). Intracellular loss of potassium in Candida albicans after exposure to polyene antifungal antibiotics. Appl. Microbiol. 14:953-956. 1966.-Eleven antifungal antibiotics, representing three broad macrolide classes, were studied in Candida albicans for their effect on growth and on the fate of intracellular K+. Marked differences ...
متن کاملthe underlying structure of language proficiency and the proficiency level
هدف از انجام این تخقیق بررسی رابطه احتمالی بین سطح مهارت زبان خارجی (foreign language proficiency) و ساختار مهارت زبان خارجی بود. تعداد 314 زبان آموز مونث و مذکر که عمدتا دانشجویان رشته های زبان انگلیسی در سطوح کارشناسی و کارشناسی ارشد بودند در این تحقیق شرکت کردند. از لحاظ سطح مهارت زبان خارجی شرکت کنندگان بسیار با هم متفاوت بودند، (75 نفر سطح پیشرفته، 113 نفر سطح متوسط، 126 سطح مقدماتی). کلا ...
15 صفحه اولN-glycosyl derivatives of polyene macrolide antibiotics.
Sir: The polyene macrolides are known as potent antifungal agents. However their use in therapy is limited by considerable toxicity and very poor water solubility. Many efforts had been taken to obvert these undesirable properties1-5). We report now a new group of derivatives of polyene macrolides exhibiting improved solubility in water and organic solvents and retaining the biological activity...
متن کاملThe mechanism of the hemolytic activity of polyene antibiotics.
The kinetics of the filipin-, amphotericin B- and nystatin-induced hemolysis of human erythrocytes were investigated. Filipin-induced hemolysis is of the damage type. It is an all-or-none process, partly inhibited by Ca2+ or Ba2+ but not by Mg2+, Na+ or SO42-. The hemolytic activity of filipin is explained by the formation of large aggregates within the erythrocyte membrane in the form of large...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1977
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.30.146